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Nutrition during incretin-based therapy

Eat enough. Protect your muscles. Build habits that work for you. Medicines such as GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists can support weight loss and improve health. However, reduced appetite and digestive symptoms can make it harder to meet your nutritional needs. During weight loss, eating well and staying active are important for preserving muscle, strength and physical function. Your needs may change throughout treatment, so ask a healthcare professional for advice tailored to you.
November 1, 2026 by

1. Protein: keep your muscles

Make protein a priority

During active weight loss, the consensus suggests around 1.0–1.5 g protein per kg of adjusted body weight per day, with at least 60 g/day as a practical minimum. Your target may differ; ask a healthcare professional, especially if you have kidney disease.

Aim for about 25–30 g at each main meal where possible. If you feel full quickly, eat the protein-rich part first. Choose foods you enjoy: yoghurt and other dairy foods, eggs, fish, lean meat, tofu, beans or lentils.

Eat regularly, even with less appetite

Smaller portions may feel more comfortable. Plan regular meals or smaller eating occasions across the day instead of skipping meals. Try to include protein and nutrient-rich foods each time.

Build balanced meals with vegetables or fruit, fibre-rich foods, protein and some healthy fats. The consensus gives a practical fibre target of at least 25 g/day. Increase fibre gradually if your gut is sensitive.

2. Regular meals, smaller portions

3. Stay active

Move in a way that suits you

Movement and protein work together to support muscle and strength. Start from what you can comfortably do now, then build up gradually. Short walks, getting up more often and simple strength exercises can be starting points.

Choose activities that fit your interests, fitness, symptoms and daily life. If possible, include strength exercises and increase the challenge at your own pace. A healthcare professional can help you adapt activity.

Drink enough and notice symptoms

A typical fluid guide is around 2.0–2.5 litres per day, unless a healthcare professional has advised otherwise. Sip regularly, especially if you have nausea, diarrhoea or constipation.

Smaller meals may help with stomach discomfort. If vomiting persists, you cannot drink enough, or you are eating very little, contact your healthcare professional promptly.

4. Drink enough

Take home message

Protein at every meal

Protein first if you fill up quickly

Balanced food and enough fluids

Activity built around your abilities and preferences

Source:

Dobbie LJ et al. Nutritional, functional, and psychological considerations for incretin-based therapies in adults—an EASO, EFAD, and ECPO Consensus Statement. The Lancet Diabetes & Endocrinology. 2026. doi:10.1016/S2213-8587(26)00122-1

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